Human leukocyte elastase inhibitors: designed variants of human pancreatic secretory trypsin inhibitor (hPSTI).
نویسندگان
چکیده
Variants of human secretory trypsin inhibitor were constructed with the aim of producing inhibitors specific for human leukocyte elastase. Models of the hPSTI/HLE and hPSTI/chymotrypsin complexes were generated by computer aided protein design and used to plan better HLE inhibitors. This resulted in the production of the strongest and most specific inhibitors of HLE known.
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عنوان ژورنال:
- Biological chemistry Hoppe-Seyler
دوره 371 Suppl شماره
صفحات -
تاریخ انتشار 1990